TIME-LIMITED RELEASE TYPE GRANULAR PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND INTRAORAL RAPID DISINTEGRATION TABLET CONTAINING THE COMPOSITION

摘要

Granular pharmaceutical composition comprising medicated core particles, an interlayer containing two types of water-soluble components consisting of an insolubilization accelerator and an insolubilization substance and an outermost layer of water infiltration amount controlling layer containing a water-insoluble substance. Thus, there can be provided a granular pharmaceutical composition for oral administration that is capable of suppressing initial drug elution, realizing subsequent rapid drug release and arbitrarily controlling a lag time, and provided an intraoral rapid disintegration tablet containing this composition. Accordingly, the drug release in the buccal cavity can be suppressed, so that any unpleasant feeling caused by drugs of unpleasant taste can be alleviated, thereby attaining compliance enhancement, etc.