| 摘要 |
The invention provides articles of manufacture which are arrays, reagents, kits, and methods for diagnosis and/or prognosis of diseases with genomic aberrations. The methods of the invention identify differences between DNA samples from normal and disease tissues that are ascertained using comparative genomic hybridization (CGH) with microarrays of genomic fragments covering the whole genome of an organism, or microarrays containing subsets of the genome that are identified by the methods herein, for example, the long arm of chromosome 2 associated with prostate cancer. The detected genomic aberrations, are correlated to specific clinical outcomes, such that specific patterns of genomic aberration-disease association are identified in the majority of samples. The invention also provides genomic DNA arrays encompassing regions, the aberration of which was correlated to specific disease outcomes, for diagnosis/prognosis of such diseases. |
