PROCESS FOR PREPARING DIPEPTIDYL IV INHIBITORS AND INTERMEDIATES THEREFOR
摘要
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure (3) prepared by subjecting an acid of the structure (1) to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure (2) with di-tert-butyl dicarbonate to form the BOC-protected amine.
申请公布号
WO2005106011(A2)
申请公布日期
2005.11.10
申请号
WO2005US12615
申请日期
2005.04.13
申请人
BRISTOL-MYERS SQUIBB COMPANY;POLITINO, MICHAEL;CADIN, MATTHEW M.;SKONEZNY, PAUL M.;CHEN, JASON G.
发明人
POLITINO, MICHAEL;CADIN, MATTHEW M.;SKONEZNY, PAUL M.;CHEN, JASON G.