发明名称 |
DPI FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN |
摘要 |
An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE - CD-containing particles dissociate from the active agent-containing particle s in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical an d morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier. |
申请公布号 |
CA2562585(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
CA20052562585 |
申请日期 |
2005.04.22 |
申请人 |
CYDEX, INC. |
发明人 |
THOMPSON, DIANE O.;HICKEY, ANTHONY J.;ZIMMERER, RUPERT O.;SMYTH, HUGH D. C.;PIPKIN, JAMES D. |
分类号 |
A61K47/40;A61K9/00;A61K9/72;A61K31/573;A61K45/06 |
主分类号 |
A61K47/40 |
代理机构 |
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代理人 |
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主权项 |
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