Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds

摘要

The present invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound in amorphous form and an amphiphilic polymer which wraps the active compound such that non-valent bonds are formed between the active compound and the amphiphilic polymer. The invention further provides hydrophilic dispersions comprising said inclusion complexes, particularly of pharmaceutical drugs, and stable pharmaceutical compositions comprising said dispersions of the pharmaceutical drugs in amorphous form.