| 摘要 |
This invention relates to a method for detecting cancer cells in a subject. The method includes contacting a plurality of cells in a sample obtained from the subject with carbazole compounds of the following formula: and calculating the percentage of the cells that emit florescence upon irradiation with an excitation light, in which, if the percentage is above a pre-set value, the subject is determined to contain cancer cells. In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R<SUB>1</SUB>-R<SUB>6</SUB>, independently, is H, C<SUB>1</SUB>-C<SUB>8 </SUB>alkyl, C<SUB>2</SUB>-C<SUB>8 </SUB>alkenyl, C<SUB>2</SUB>-C<SUB>8 </SUB>alkynyl, C<SUB>3</SUB>-C<SUB>8 </SUB>cycloalkyl, C<SUB>3</SUB>-C<SUB>8 </SUB>heterocycloalkyl, aryl, heteroaryl, OH, C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, aryloxy, heteroaryloxy, NH<SUB>2</SUB>, C<SUB>1</SUB>l-C<SUB>6 </SUB>alkylamino, C<SUB>1</SUB>-C<SUB>12 </SUB>dialkylamino, arylamino, diarylamino, or halogen; R<SUB>7 </SUB>is H, C<SUB>1</SUB>-C<SUB>8 </SUB>alkyl, C<SUB>2</SUB>-C<SUB>8 </SUB>alkenyl, C<SUB>2</SUB>-C<SUB>8 </SUB>alkynyl, C<SUB>3</SUB>-C<SUB>8 </SUB>cycloalkyl, C<SUB>3</SUB>-C<SUB>8 </SUB>heterocycloalkyl, aryl, heteroaryl; and each of m and n, independently, is 1, 2, or 3.
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