NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF

摘要

It is intended to compounds having a p38MAP kinase inhibitory activity. Because of having a p38MAP kinase inhibitory activity, compounds represented by the general formula (I), salts thereof, N-oxide derivatives thereof, solvates thereof or prodrugs thereof are useful in preventing and/or treating diseases the occurrence or worsening of the pathological conditions of which seemingly relates to abnormal production of cytokines such as inflammatory cytokines and chemokines or overresponses thereto, that is, cytokine-mediated diseases such as inflammatory diseases, respiratory diseases, circulatory diseases and bone diseases. General formula (I) [Chemical formula 1] (I) [wherein each symbol is as defined in the description.]