发明名称 |
CASPASE-2 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS |
摘要 |
The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone : 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Vanilyl-L-Alaniny l- L-Aspartyl (methyl ester) 2,6-difluorophenyl ester (SEQ1) and derivatives thereof, SEQ 1 corresponding to formulae (Ia) or (Ib). Application of said inhibitors for preventing and treating diseases involving caspase-2.
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申请公布号 |
CA2564177(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
CA20052564177 |
申请日期 |
2005.05.02 |
申请人 |
THERAPTOSIS |
发明人 |
CASIMIR, RICHARD;CHAUVIER, DAVID;REBOUILLAT, DOMINIQUE;JACOTOT, ETIENNE |
分类号 |
C07K14/81;A61K38/57;A61P25/28;C07K7/00;C07K14/47 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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