The present invention relates in part to immunostimulatory nucleic acids linked to a lipophilic group. It has been deiscovered that specific immunostimulatory nucleic acids linked to lipophilic groups have enhanced activity, whereas the linkage of lipophilic groups to other immunostimulatory nucleic acids has minimal effect on the immunostimulatory capability of the molecule.
申请公布号
WO2005030259(A3)
申请公布日期
2005.11.10
申请号
WO2004US31748
申请日期
2004.09.27
申请人
COLEY PHARMACEUTICAL GROUP, INC.;COLEY PHARMACEUTICAL GMBH;VOLLMER, JOERG;KRIEG, ARTHUR, M.;UHLMANN, EUGEN