PROCOLLAGEN II BIOMARKERS AND METHODS

摘要

A method of prediction disease progression in a disorder characterized by the uncoupling of collagen type II synthesis and degradation is disclosed. There is further disclosed a method of detecting specific procollagen fragments associated with osteoarthritis. The fragments are derived from procollagen type IIB (PIIBNP). A method for determining the efficacy of an agent or drug intended to decrease or inhibit a collagenase enzyme is disclosed.