| 摘要 |
<p>Described is an osteoinductive implant for for the treatment of pathological changes or conditions of bones and/or intervertebral discs and/or cartilage, in particular implants for regeneration and stabilization of the anatomic features in case of bone fractures caused by external force, osteotomy or pathological changes or con-ditions, such as for the treatment of the spinal column, for cranial and maxillo-facial applications, dental ap-plications, joint surgery, indications in hollow bones (long bones) and extremities. Said implant comprises at least one secretion inducing substance that induces the secretion of bone and/or cartilage growth stimulating peptides such as growth factors and/or bone morphogenetic proteins, in particular at least one statin. In a preferred embodiment, the implant is provided with an abrasion-resistant coating comprising a resorbable polymer and at least part of the secretion in-ducing substance.</p> |
