Synthesis and uses of synephrine derivatives

摘要

The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by beta₃-adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.