发明名称 |
PROCESS FOR PREPARING DIPEPTIDYL IV INHIBITORS AND INTERMEDIATES THEREFOR |
摘要 |
A process for preparing an amine of the structure
which comprises
a. treating an aqueous solution of a keto acid of the structure
with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and
b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions. |
申请公布号 |
CA2563903(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
CA20052563903 |
申请日期 |
2005.04.13 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SKONEZNY, PAUL M.;CHEN, JASON G.;CADIN, MATTHEW M.;POLITINO, MICHAEL |
分类号 |
C07D209/04;C07H21/04;C12N1/06;C12N1/20;C12N1/21;C12N9/02;C12N9/06;C12N15/74;C12P13/04;C12P13/22;C12P15/00;C12P17/10;C12P21/06 |
主分类号 |
C07D209/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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