METHOD OF SCREENING THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE

摘要

A method of screening a substance capable of inhibiting any binding between protein with S-100beta binding capacity and S-100beta, comprising bringing a protein with S-100beta binding capacity into contact with S-100beta in the presence and absence of an analyte, measuring the levels of binding between protein with S-100beta binding capacity and S-100beta in two instances, and comparing them to each other. The substance obtained by this screening method, partial peptide from the protein of the invention, antibody capable of inhibiting any binding between the protein and S-100beta and polynucleotide comprising the base sequence, or part thereof, complementary to the polynucleotide coding for the protein are useful in the treatment and diagnosis of, for example, neurodegenerative diseases, such as Alzheimer's Disease, Parkinson's disease and amyotrophic lateral sclerosis.