发明名称 |
Cdc7-ask kinase complex, substrates of the kinase complex, antibody specific to the substrate, and method of screening compound capable of inhibiting cdc7-ask kinase using the same |
摘要 |
The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex can also be evaluated based on these measurement methods. Compounds that inhibit this phosphorylation activity are useful as anti-cancer agents having superior specificity for cancer.
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申请公布号 |
US2005250166(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
US20050507275 |
申请日期 |
2005.06.08 |
申请人 |
MEDICAL AND BIOLOGICAL LABORATORIES CO. LTD. |
发明人 |
MASAI HISAO;TAMAI KATSUYUKI |
分类号 |
A61P35/00;A61P43/00;C12N9/12;C12N15/12;C12Q1/48;(IPC1-7):C12Q1/48;C07H21/04;C12N15/09;C12N9/99 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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