发明名称 |
Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases |
摘要 |
A combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (i) an adenosine A<SUB>2A </SUB>receptor agonist; and (ii) an anti-cholinergic agent, preferably comprising a member selected from the group consisting of tiotropium and derivatives thereof; the combination being therapeutically effective in the treatment of the diseases when administered by inhalation; as well as to a method of treating the obstructive airways and other inflammatory diseases comprising administering separately, simultaneously or sequentially to the mammal by inhalation a therapeutically effective amount of the combination of therapeutic agents; as well as to a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with the combination of therapeutic agents; as well as to a product containing the compounds of the combination for separate, simultaneous or sequential administration by inhalation to a mammal for the treatment of obstructive airways and other inflammatory diseases. It is preferred that the anti-cholinergic agent component be tiotropium bromide.
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申请公布号 |
US2005250730(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
US20040991634 |
申请日期 |
2004.11.18 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG |
发明人 |
YEADON MICHAEL;WATSON JOHN W.;ARMSTRONG ROISON A. |
分类号 |
C07H19/167;A61K9/00;A61K31/46;A61K31/52;A61K31/7076;A61K45/06;A61P11/00;A61P11/06;A61P11/08;A61P29/00;C07D451/12;(IPC1-7):A61K31/707 |
主分类号 |
C07H19/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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