发明名称 |
Polymer conjugates of interferon beta-1a and uses |
摘要 |
An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
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申请公布号 |
US6962978(B2) |
申请公布日期 |
2005.11.08 |
申请号 |
US20010832658 |
申请日期 |
2001.04.11 |
申请人 |
BIOGEN, INC. |
发明人 |
PEPINSKY BLAKE;RUNKEL LAURA;BRICKELMAIER MARGOT;WHITTY ADRIAN;HOCHMAN PAULA |
分类号 |
A61K38/19;A61K38/21;A61K39/395;A61K47/48;A61P1/16;A61P9/00;A61P29/00;A61P31/12;A61P35/00;A61P37/00;A61P43/00;C07K14/565;C07K16/00;C07K19/00;(IPC1-7):C07K14/52;C07K14/555 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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