| 摘要 |
Medicines for treatment or prevention of dementia comprising 2-aryl-8-oxodihydropurine derivatives of the formula (I): wherein W is H, C<SUB>1-6 </SUB>alkyl, halogen, C<SUB>1-6 </SUB>alkoxy, or the like; X is H, C<SUB>1-6 </SUB>alkyl, a group of the formula (Q): -CH(R<SUP>3</SUP>)CON(R<SUP>1</SUP>) (R<SUP>2</SUP>) (wherein R<SUP>1 </SUP>is a C<SUB>1-6 </SUB>alkyl or the like; R<SUP>2 </SUP>is phenyl-substituted C<SUB>1-4 </SUB>alkyl or the like; and R<SUP>3 </SUP>is H or the like); Y is H, C<SUB>1-6 </SUB>alkyl, a group of the above formula (Q), or the like; and A is substituted phenyl or the like, with the proviso that one of X and Y is a group of the formula (Q) and the other is a group selected from those defined for X or Y except the groups (Q), or pharmaceutically acceptable acid addition salts thereof. The above compounds exhibit an extremely potent ameliorating effect on learning disorder and/or dymnesia and thus are useful in the treatment or prevention of Alzheimer-type dementia, cerebrovascular dementia, senile dementia, etc.
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