摘要 |
Pharmaceutically useful compounds having ACAT inhibitory activity of formula (I), wherein n is 0, 1 or 2, for X other than tetrazole and n = 2 then R2 = R3 = H; R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R2 and R3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.
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申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
LEE, HELEN TSENWHEI;O'BRIEN, PATRICK MICHAEL;PICARD, JOSEPH ARMAND;PURCHASE, CLAUDE FORSEY, JR.;ROTH, BRUCE DAVID;SLISKOVIC, DRAGO ROBERT;WHITE, ANDREW DAVID |