发明名称 |
Pyrrolopyrimidinone derivatives, process of preparation and use |
摘要 |
The invention relates to a series of pyrrolopyrimidinone derivatives of the formula ( 1 ): wherein R<SUP>1 </SUP>is H; C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl optionally substituted with one or more fluoro atoms; or C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl; R<SUP>2 </SUP>is H; a halogen atom; C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl optionally substituted with OH, C<SUB>1</SUB>-C<SUB>3 </SUB>alkoxy, C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl, or with one or more fluoro atoms; C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl; C<SUB>2</SUB>-C<SUB>6 </SUB>alkenyl; or C<SUB>2</SUB>-C<SUB>6 </SUB>alkynyl; R<SUP>3 </SUP>is H; C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl optionally substituted with OH, C<SUB>1</SUB>-C<SUB>3 </SUB>alkoxy, C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl, or with one or more fluoro atoms; C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl; C<SUB>2</SUB>-C<SUB>6 </SUB>alkenyl; or C<SUB>2</SUB>-C<SUB>6 </SUB>alkynyl; R<SUP>4 </SUP>is C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl optionally substituted with C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl or with one or more fluoro atoms; C<SUB>2</SUB>-C<SUB>6 </SUB>alkenyl; C<SUB>2</SUB>-C<SUB>6 </SUB>alkynyl; or C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl; and R<SUP>5 </SUP>is SO<SUB>2</SUB>NR<SUP>6</SUP>R<SUP>7</SUP>; NHSO<SUB>2</SUB>NR<SUP>6</SUP>R<SUP>7</SUP>; NHCOCONR<SUP>6</SUP>R<SUP>7</SUP>; NHSO<SUB>2</SUB>R<SUP>8; </SUP>NHCOR<SUP>8; </SUP>or phenyl or heterocyclyl either of which is optionally substituted with one or more fluoro atoms or C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl.
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申请公布号 |
US6962911(B2) |
申请公布日期 |
2005.11.08 |
申请号 |
US20020204327 |
申请日期 |
2002.12.02 |
申请人 |
IN2GEN CO., LTD. |
发明人 |
KIM DAE-KEE;LEE JU YOUNG;RYU DO HYUN;LEE NAM KYU;LEE SUK HO;KIM NAM-HO;KIM JAE-SUN;RYU JE HO;CHOI JIN-YOUNG;IM GUANG-JIN;CHOI WON-SON;KIM TAE KON;CHA HOON |
分类号 |
A61K31/51;A61K31/519;A61K31/551;A61P1/04;A61P9/00;A61P9/04;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P15/00;A61P15/10;A61P15/14;A61P27/02;A61P29/00;A61P37/08;A61P43/00;C07D207/00;C07D207/34;C07D239/00;C07D487/04;(IPC1-7):C07D487/04;A61P27/06 |
主分类号 |
A61K31/51 |
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