摘要 |
<p>Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.</p> |
申请人 |
NEUROCRINE BIOSCIENCES, INC.;GOODFELLOW, VAL;DYCK, BRIAN, P.;ZHAO, LIREN;TAMIYA, JUNKO;GREY, JONATHAN;WADE, WARREN;ROWBOTTOM, MARTIN;ZHANG, MINGZHU;VICKERS, TROY, D.;PONTILLO, JOSEPH.;HUDSON, SARAH, C.;CHING, BRETT, WEYLAN. |
发明人 |
GOODFELLOW, VAL;DYCK, BRIAN, P.;ZHAO, LIREN;TAMIYA, JUNKO;GREY, JONATHAN;WADE, WARREN;ROWBOTTOM, MARTIN;ZHANG, MINGZHU;VICKERS, TROY, D.;PONTILLO, JOSEPH.;HUDSON, SARAH, C.;CHING, BRETT, WEYLAN. |