ACYL DIHYDRO PYRROLE DERIVATIVES AS HCV INHIBITORS

摘要

Novel anti-viral agents of Formula (I) in which: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or C1-6alkyl optionally substituted by one or more substituents selected from halo, OR<1>, SR<1>, C(O)NR<2>R<3>, CO2H, C(O)R<4>, CO2R<4>, NR<2>R<3>, NHC(O)R<4>, NHCO2R<4>, NHC(O)NR<5>R<6>, SO2NR<5>R<6>, SO2R<4>, nitro, cyano, aryl, heteroaryl and heterocyclyl; R<1> represents hydrogen, C1-6alkyl, arylalkyl, or heteroarylalkyl; R<2> and R<3> are independently selected from hydrogen, C1-6alkyl, aryl and heteroaryl; or R<2> and R<3> together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R<4> is selected from the group consisting of C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R<5> and R<6> are independently selected from the group consisting of hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R<5> and R<6> together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.