发明名称 |
MODULATORS OF PARAPTOSIS AND RELATED METHODS |
摘要 |
The invention is directed to a method of identifying a compound that modulates SP-induced paraptosis by (a) contacting a population of cells with an effective amount of substance P to induce SP-induced paraptosis; (b) contacting a first sub-population of the cells with a test-compound, and a second sub-population of the cells with a control-compound; and (c) comparing the amount of cell death between the first and second sub-populations of cells, where a difference in the amount of cell death between the first and second sub-populations of cells indicates that the test-compound is a compound that modulates SP-induced paraptosis. The invention is also directed to a method of treating a condition associated with excessive cell accumulation by administering to a subject in need of such treatment an effective amount of a compound identified from the method described above where the effective amount of the compound increases SP-induced paraptosis. The invention is further directed to a method of treating a condition associated with excessive cell death by administering to a subject in need of such treatment an effective amount of a compound identified from the method described above where the effective amount of the compound decreases SP-induced paraptosis.
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申请公布号 |
US2005244894(A1) |
申请公布日期 |
2005.11.03 |
申请号 |
US20020202503 |
申请日期 |
2002.07.23 |
申请人 |
SPERANDIO SABINA;CASTRO-OBREGON SUSANA;BREDESEN DALE E |
发明人 |
SPERANDIO SABINA;CASTRO-OBREGON SUSANA;BREDESEN DALE E. |
分类号 |
A61K31/00;A61K31/198;A61K31/40;A61K31/421;A61K31/739;A61K38/04;A61K38/17;A61K38/19;A61K38/48;A61K45/06;G01N33/50;(IPC1-7):C12Q1/68;G01N33/53;G01N33/567 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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