The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.
申请公布号
WO2005102387(A2)
申请公布日期
2005.11.03
申请号
WO2004US37430
申请日期
2004.11.08
申请人
PROTEIN DESIGN LABS, INC.;WILLIAMS, MARNA;TSO, J. YUN;LANDOLFI, NICHOLAS F.;POWERS, DAVID B.;DUBRIDGE, ROBERT B.;LAW, DEBBIE;LIU, GAO
发明人
WILLIAMS, MARNA;TSO, J. YUN;LANDOLFI, NICHOLAS F.;POWERS, DAVID B.;DUBRIDGE, ROBERT B.;LAW, DEBBIE;LIU, GAO