| 发明名称 |
Cell based assay |
| 摘要 |
The present invention provides a whole-cell biological assay that measures changes of endogenous genes under control of an exogenously introduced transcription factor. The exogenous transcription factors of the present invention may be designed such that each is activated by specific extracellular ligands. Therefore cells containing exogenous transcription factors of the present invention provide a generic means to which many extracellular ligands may be tested without undue adaptation to the assay.
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| 申请公布号 |
US2005244859(A1) |
申请公布日期 |
2005.11.03 |
| 申请号 |
US20050081049 |
申请日期 |
2005.03.14 |
| 申请人 |
ORTHO MCNEIL PHARMACEUTICAL, INC. |
发明人 |
ZHONG ZHONG;KELLEY GLEN L.;MERCOLINO THOMAS J.;ZIVIN ROBERT;SIEKIERKA JOHN J. |
| 分类号 |
G01N33/50;A61K38/00;A61K38/21;A61K45/00;A61K48/00;A61P43/00;C07K14/47;C07K16/18;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;C12Q1/28;C12Q1/37;C12Q1/42;C12Q1/68;G01N33/15;(IPC1-7):C12Q1/68;C07H21/04;C12P21/06;C12N9/22 |
主分类号 |
G01N33/50 |
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