发明名称 |
CANCER SPECIFIC PROMOTERS |
摘要 |
The present invention regards cancer-specific control sequences that direct expression of a polynucleotide encoding a therapeutic gene product for treatment of the cancer. Specifically, the invention encompasses breast cancer-, prostate cancer-, and pancreatic cancer-specific control sequences. Two breast cancer-specific sequences utilize specific regions of topoisomerase IIalpha and transferrin receptor promoters, particularly in combination with an enhancer. The prostate cancer-specific and pancreatic cancer-specific control sequences utilize composites of tissue-specific control sequences, a two-step transcription amplification sequence, and a post-transcriptional control sequence. In more particular embodiments, these polynucleotides are administered in combination with liposomes. |
申请公布号 |
WO2005103251(A2) |
申请公布日期 |
2005.11.03 |
申请号 |
WO2005US11067 |
申请日期 |
2005.04.01 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;HUNG, MIEN-CHIE;DAY, CHI-PING;RAU, KUN-MING;XIE, XIAOMING;LI, ZHENG |
发明人 |
HUNG, MIEN-CHIE;DAY, CHI-PING;RAU, KUN-MING;XIE, XIAOMING;LI, ZHENG |
分类号 |
C07H21/04;C07K14/705;C07K14/82;C12N9/00;C12N9/22;C12N15/09;C12N15/10;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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