发明名称 |
UNIVERSAL TARGET SEQUENCES FOR siRNA GENE SILENCING |
摘要 |
<p>The present invention provides methods for designing a sequence for efficient short interference RNA molecules. In particular, the present invention defines a universal target for siRNA derived from the consensus sequence of the polyadenylation signal in conjunction with unique sequences for gene silencing and inhibition of viral replication in a eukaryotic host cell. The present invention further provides methods for the treatment and prevention of diseases and disorders by silencing a gene of a virus, an oncogene, genes encoding transcription factors and many other diseases related genes.</p> |
申请公布号 |
WO2005103254(A1) |
申请公布日期 |
2005.11.03 |
申请号 |
WO2005IL00437 |
申请日期 |
2005.04.21 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM;HONIGMAN, ALIK;PANET, AMOS;LEVAOT, NOAM |
发明人 |
HONIGMAN, ALIK;PANET, AMOS;LEVAOT, NOAM |
分类号 |
C12N15/11;(IPC1-7):C12N15/11;A61K31/713 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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