NOVEL SYNTHETIC C-GLYCOLIPIDS, THEIR SYNTHESIS AND USE TO TREAT INFECTIONS, CANCER AND AUTOIMMUNE DISEASES

摘要

The invention is directed to novel compounds of formulae (I), (II) and (III) : wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.