| 发明名称 |
ANTISENSE OLIGONUCLEOTIDES AGAINST CPLA2, COMPOSITIONS AND USES THEREOF |
| 摘要 |
Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases. |
| 申请公布号 |
CA2563741(A1) |
申请公布日期 |
2005.11.03 |
| 申请号 |
CA20052563741 |
申请日期 |
2005.04.17 |
| 申请人 |
BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY;MOR RESEARCH APPLICATIONS LTD. |
发明人 |
LEVY, RACHEL |
| 分类号 |
C07H21/04;A61K31/7088;A61K48/00;A61P9/10;A61P25/28;A61P29/00;A61P31/00;C12N;C12N9/16;C12N15/113;C12N15/55;C12Q1/68 |
主分类号 |
C07H21/04 |
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