发明名称 |
CULTURED PERIODONTAL MEMBRANE CELL SHEET, PROCESS FOR PRODUCING THE SAME AND METHOD OF USE THEREOF |
摘要 |
<p>A cultured periodontal membrane cell sheet, produced through a process comprising culturing cells on a cell culture support composed of a base material having its surface coated with a temperature-responsive polymer of 0˚C to 80˚C upper limit or lower limit critical dissolution temperature in water under specified conditions, (1) regulating the temperature of culture fluid to temperature >= the upper limit critical dissolution temperature or <= the lower limit critical dissolution temperature, (2) causing a cultured periodontal membrane cell sheet resulting from the culturing to adhere to a carrier, and (3) detaching the sheet together with the carrier. This cultured periodontal membrane cell sheet has a syndesmotic microstructure, exhibiting extremely high bioadherence to the surface of dental root, and realizes high-density transplant of target cells and positive reconstruction of periodontal tissue. Moreover, through laminating of cell sheets to be transplanted and donating of three-dimensional polarity, highly efficient reconstruction of attachment apparatus can be accomplished, and clinical application thereof to moderate periodontitis, severe periodontitis, gingival recession, etc. is highly promising.</p> |
申请公布号 |
WO2005103233(A1) |
申请公布日期 |
2005.11.03 |
申请号 |
WO2005JP07853 |
申请日期 |
2005.04.25 |
申请人 |
OKANO, TERUO;HASEGAWA, MASATERU;YAMATO, MASAYUKI;KIKUCHI, AKIHIKO;ISHIKAWA, ISAO |
发明人 |
OKANO, TERUO;HASEGAWA, MASATERU;YAMATO, MASAYUKI;KIKUCHI, AKIHIKO;ISHIKAWA, ISAO |
分类号 |
A61C5/08;A61C5/10;A61C8/00;A61K35/12;A61K35/32;A61L27/38;A61P1/02;C12N5/077;(IPC1-7):C12N5/06 |
主分类号 |
A61C5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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