PYRIMIDIN-4-YL-1H-INDAZOL-5YL-AMINES AS CHK1 KINASES INHIBITORS

摘要

Compounds of Formula (I) wherein, R1 can be hydrogen, optionally substituted alkyl, optionally substituted alkoxy, OCF3, CF3, amino, optionally substituted aryloxy, halogen, hydroxy, CN, CO2H, NR<4>R<5>, CO2R<4>, CONR<4>R<5>, NR<4>(CO)R<5> or S(O)PR<4>; wherein R<4> and R<5>, which can be the same or different, can be hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroarylalkyl or optionally substituted arylalkyl; and wherein p is 1 or 2; R1 can be in the 3-, 4-, 6- or 7-position of the indazol ring; and R2 is optionally substituted aryl or optionally substituted heteroaryl are useful in the inhibition of protein kinases, in particular serine/threonine kinases, more particularly Chk1 kinase. The compounds can be used in medicine and particularly in the prevention and/or treatment of a wide variety of diseases including cancer, and disease states associated with angiogenesis and/or cellular proliferation.