Alkynylated fused ring pyrimidine compounds

摘要

A compound selected from those of formula (I): wherein W₁ represents O, S, or -NR₃ in which R₃ represents hydrogen, alkyl, OH or CN; W₂ represents a group selected from hydrogen, CF₃, NH₂, monoalkylamino, dialkylamino, alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkylalkyl, heterocycle, these groups being optionally substituted, or W₁ and W₂ form together a group of formula -N-X₄-W₃- as defined in the description, X₁, X₂ and X₃ represent N or C optionally substituted, n is 0 to 8, Z represents -CR₁₂R₁₃, wherein R₁₂ and R₁₃ are as defined in the description, A represents a ring system, the groups R₂ represent hydrogen or various chemical groups as defined in the description, q is 0 to 7; R₁ represents hydrogen, alkyl, alkenyl, alkynyl, or a ring system, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix metalloprotease.