Method of screening insulin resistance inproving drug

摘要

A method for identifying and screening a novel substance promoting the transcription induction activity of PPARgamma and improving insulin resistance by promoting the interaction between PPAR promoting the transcription induction activity of PPARgamma and p68 RNA helicase and/or promoting the expression of p68RNA helicase is disclosed. The method is a new type method for screening an agent for improving insulin resistance by promoting the transcription induction activity of PPARgamma which is different from the conventional PPAR agonist. Furthermore, the method for producing a pharmaceutical composition for improving insulin resistance which comprises the substance obtainable by the above method for screening as an active ingredient is disclosed.