发明名称 |
B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION |
摘要 |
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL2 and splice variants thereof. The present invention further provides isolated B7-related polypeptides that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for diagnostic applications and the immunomodulation of a human or animal subject. |
申请公布号 |
EP1519942(A4) |
申请公布日期 |
2005.11.02 |
申请号 |
EP20020739753 |
申请日期 |
2002.06.06 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MIKESELL, GLEN, E.;SHEN, HENRY |
分类号 |
A61K38/00;C07K14/705;C07K16/28;C12N1/21;C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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