发明名称 |
PROCESS FOR PURIFYING OLIGONUCLEOTIDE SYNTHONS |
摘要 |
<p>A process for the purification of an oligonucleotide synthon is provided. The process comprises subjecting an organic solution comprising an oligonucleotide synthon and lower molecular weight impurities to nanofiltration whereby the ratio of an oligonucleotide synthon to lower molecular weight impurities in the solution is increased after the nanofiltration. Preferably, the oligonucleotide synthon is a nucleoside phosphoramidite or nucleoside H-phosphonate. The nanofiltration membrane is preferably a polyimide membrane having a molecular weight cut off of 400.</p> |
申请公布号 |
EP1590361(A2) |
申请公布日期 |
2005.11.02 |
申请号 |
EP20030780394 |
申请日期 |
2003.12.16 |
申请人 |
AVECIA LIMITED |
发明人 |
MCCORMAC, PAUL;HARGREAVES, STEPHEN;LIVINGSTON, ANDREW, GUY;BOAM, ANDREW, TIMOTHY;NAIR, DINESH |
分类号 |
C07H1/06;C07H19/06;C07H19/16;C07H21/00;(IPC1-7):C07H21/00 |
主分类号 |
C07H1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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