| 摘要 |
The present invention is directed to a process for preparation of 3-amino-2-hydroxy-1-propyl ether of the formula (see formula 4) wherein R1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsbstituted heterocyclic ring, R2 and R3 are the same or different and represent a hydrogen atom, a substituted or unsubstituted alkyl, or may form a ring together with an adjacent nitrogen atom, which ring may be interrupted with nitrogen atom, oxygen atom or sulfur atom, which is characterized by reacting an epoxy compound of the formula (see formula 1) wherein X is halogen, in the presence of a fluoride salt, with an alcohol and then reacting an amine. According to the above method, intermediates for synthesis of medicines are obtained in good yield and high optical purity.
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