NOVEL QUINOLINE CARBOXYLIC ACID DERIVATIVES HAVING 7- (4-AMINOMETHYL -3-OXIME) PYRROLIDINE SUBSTITUENTS AND PROCESSES FOR THEIR PREPARATION.

摘要

THE PRESENT INVENTION RELATES TO A NOVEL QUINOLONE COMPOUND HAVING AN EXCELLENT ANTIBACTERIAL ACITIVITY. MORE SPECIFICALLY, THE PRESENT INVENTION RELATES TO A NOVEL QUINOLINE(NAPHTHYRIDINE) CARBOXYLIC ACID DERIVATIVE REPRESENTED BY THE FOLLOWING FORMULA (I), WHICH HAS AN 4-AMINOMETHYL-3- OXIMEPYRROLIDINE SUBSTITUENT ON 7-POSITION OF THE QUINOLONE NUCLEUS AND SHOWS A SUPERIOR ANTIBACTERIAL ACTIVITY IN CONTRAST TO THE KNOWN QUINOLONE ANTIBACTRIAL AGENTS HAVING A WEAK ACTIVITY AGAINST GRAM-POSITIVE BACTERIAL STRAINS AND ALSO HAS A BROAD ANTIBACTERIAL SPECTRUM AND A HIGHLY IMPROVED PHARMACOKINETIC PROPERTY: