发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY |
摘要 |
<p>This invention provides a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal, which comprises an aqueous solution of (i) fentanyl or a pharmaceutically acceptable salt thereof and (ii) a pharmaceutically acceptable additive selected from (a) a pectin and (b) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax)that is from 10 to 80% of- that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</p> |
申请公布号 |
KR20050103275(A) |
申请公布日期 |
2005.10.28 |
申请号 |
KR20057012821 |
申请日期 |
2005.07.08 |
申请人 |
ARCHIMEDES DEVELOPMENT LIMITED |
发明人 |
CASTILE JONATHAN DAVID;WATTS PETER JAMES;LAFFERTY WILLIAM COLUMBUS IAN;SMITH ALAN |
分类号 |
A61K9/00;A61K31/4468;A61P25/04;(IPC1-7):A61K31/015 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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