Phosphatidylserine receptor from human, mouse, drosophila and caenorhabditis, its homologue or antibody for reducing inflammation, treating autoimmune disease and increasing anti-tumour immunity

摘要

Disclosed are phosphatidylserine (PS) receptors, including PS receptors from human, mouse, Drosophila melanogaster and Caenorhabditis elegans. Also disclosed are homologues of such receptors, nucleic acids encoding such receptors and homologues thereof, as well as agonist and antagonist compounds that specifically associate with and affect the activation state of such receptors. Preferred agonists and antagonists of PS receptors include antibodies, antibody fragments and binding partners that selectively bind to such a receptor. Also disclosed are methods of making and using the PS receptors, homologues thereof, and agonist and antagonist compounds of such receptors. In particular, the use of the compounds for reducing inflammation, for treating an autoimmune disease, for enhancing transplantation of tissue grafts, methods of increasing anti-tumour immunity, and methods for inhibiting viral and parasitic infections are described.