Pharmaceutical products, preparation and uses thereof

摘要

Disclosed is: 1) an oral dosage form comprising at least one therapeutic agent in crystalline form said dosage form comprising at least one reticulated three-dimensional microstructure comprising: a network of substantially interconnecting walls, said walls being provided; and a multiplicity of pores defined by said substantially interconnecting walls. 2) the use of at least one reticulated three-dimensional microstructure as a physiologically acceptable support for crystals of a therapeutic agent, which reticulated microstructure comprises: a network of substantially interconnecting walls, said walls being provided by a multiplicity of crystals arranged to at least partially abut each other, said crystals defining said walls comprising crystals of a physiologically acceptable support material; and a multiplicity of pores defined by said substantially interconnecting walls. 3) a process of preparing an oral dosage form as defined in any of claims 1 to 20, which process comprises: forming an emulsion comprising (i) a first phase, (ii) a second phase substantially immiscible with said first phase, and (iii) at least one surfactant; which first phase defines a network of substantially interconnected emulsion channels and comprises a solution comprising at least one therapeutic agent; allowing at least crystals of said at least one therapeutic agent to form in said emulsion channels, whereby a multiplicity of crystals are formed so as to at least partially abut each other so as to be capable of forming the walls of at least one three-dimensional reticulated microstructure; and recovering said crystals from said emulsion.