| 摘要 |
Process for the production of piperidine derivatives compound having a structure according to formulae (IA) and/or (IB) is disclosed, wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is -COOH or -COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy, wherein the process involves incubating a starting compound having a structure according to formulae (IIA) and/or (IIB) wherein R3 is -CH3 and R1, R2, A, B, and D are defined above, in the presence of a microorganism under conditions effective to produce the product compound, wherein the microorganism can be from the genus Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Psuedomonas, Helicostylum, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Pennicillium. Alternatively, the microorganism can be Cunninghamella bainieri.
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