Controlled release hydrocodone formulations

摘要

Disclosed is a solid controlled-release oral dosage form, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and a controlled release material to render said dosage form suitable for twice-a-day administration to a human patient, said controlled release material comprising a hydrophobic material, a hydrophilic material, or a combination thereof said dosage form after a first administration to a human patient providing a C12/Cmax ratio of 0.55 to 0.85, and said dosage form providing an early onset therapeutic effect for at least about 12 hours. (62) Divided out of 518631