| 摘要 |
PROBLEM TO BE SOLVED: To provide magnetic beads deflocculating specimens at a low temperature causing no degeneration nor destruction and capable of preventing degeneration and destruction of the specimens, and to provide a method for isolating the specimens by using the beads. SOLUTION: The method comprises mixing, in a sample 14 containing a several kind of specimens 11, 12 and 13, a several kind of magnetic beads 1B1, 1B2 and 1B3 each covered with a nonmagnetic coat specifically bonding or reacting with the several kind of specimens on the surface of magnetic particles comprising ferrimagnets having compensation temperatures in each different temperature ranges, specifically bonding or reacting each specimen with each magnetic bead, then, being influenced with an external magnetic field to agglomerate superparamagnetic beads in the external magnetic field, adjusting the temperature of the mixture of the sample and the beads at the compensation temperature of the magnetic beads 1 to deflocculate the agglomerated magnetic beads 1 and taking out, under such a condition, the magnetic beads 1 and the specimens specifically bonded or reacted therewith. The steps are repeated required number of repetitions. COPYRIGHT: (C)2006,JPO&NCIPI
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