发明名称 |
MULTILAYER PHARMACEUTICAL DOSAGE FORM CONTAINING A SUBSTANCE THAT ACTS IN A MODULATORY MANNER WITH REGARD TO THE RELEASE OF ACTIVE SUBSTANCES |
摘要 |
The invention relates to a multilayer pharmaceutical dosage form for the controlled release of active substances, containing: a) a core layer containing a substance that acts in a modulatory manner with regard to the release of active substances, optionally a neutral core and/or an active substance; b) an inner control layer that influences the release of the substance that acts in a modulatory manner and of the optionally contained active substance from the core layer, containing pharmaceutically useable polymers, waxes, resins and/or proteins; c) an active substance layer containing a pharmaceutical active substance and, optionally, a substance that acts in a modulatory manner; d) an outer control layer containing a (meth)acrylate copolymer or a mixture consisting of a number of (meth)acrylate copolymers comprised of 98 to 85 C1-C4 alkyl esters of (meth)acrylic acid and 2 to 15 % by weight of methacrylate monomers with a quaternary ammonium group in the alkyl radical and optionally containing pharmaceutically useable polymers that are insoluble in water, whereby the layers can contain, in addition and in a known manner, pharmaceutically conventional adjuvants. |
申请公布号 |
WO2005046649(A3) |
申请公布日期 |
2005.10.27 |
申请号 |
WO2004EP10297 |
申请日期 |
2004.09.15 |
申请人 |
ROEHM GMBH & CO. KG;LIZIO, ROSARIO;PETEREIT, HANS-ULRICH;ASSMUS, MANFRED;RAVISHANKAR, HEMA |
发明人 |
LIZIO, ROSARIO;PETEREIT, HANS-ULRICH;ASSMUS, MANFRED;RAVISHANKAR, HEMA |
分类号 |
A61K9/24;A61K9/28;A61K9/50 |
主分类号 |
A61K9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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