POLYCATION-MODIFIED LIPOSOME AND METHOD FOR PRODUCING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a cationic liposome which does not have the problem of cytotoxicity and can be used as a gene carrier.

SOLUTION: The polycation-modified liposome prepared by modifying the surface of a liposome containing a phospholipid as a main constituent with chitosan. The method for producing the polycation-modified liposome is characterized by dropping a solution of a liposome containing a phospholipid as a main constituent in an acidic solution of chitosan. The method for producing the polycation-modified liposome is characterized by adding an aqueous phase containing a substance to be sealed in the liposome to a mixture fluid containing a phospholipid, chitosan and carbon dioxide at a temperature higher than the critical point of the carbon dioxide and/or under a pressure.

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