16-MEMBERED CYCLIC MACROLIDE DERIVATIVE AND ITS PRODUCTION METHOD

摘要

PROBLEM TO BE SOLVED: To provide a 16-membered cyclic macrolide derivative which has sufficiently high structural stability in blood plasma and enables the significant extension of in vivo half life period while maintaining the antimicrobial activity thereof on a high level. SOLUTION: There is provided the 16-membered cyclic macrolide derivative represented by general formula (1) (wherein R is H or methyl; and X is =CH-OH or =C=O) or its salt. COPYRIGHT: (C)2006,JPO&NCIPI