Triazole derivatives as tachykinin receptor antagonists

摘要

This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C₁-C₃ alkane-diyl; R¹ is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R⁴ is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)