PURIFIED INTERLEUKIN-15/Fc FUSION PROTEIN AND PREPARATION THEREOF

摘要

The present invention relates to a process for purifying an interleukin-15/Fc fusion protein from a composi­tion, which process comprises a) applying the composition to an affinity chromatography column and eluting a first IL-15/Fc eluate from the column and b) applying the eluate of step a) to an ion exchange chromatography column and eluting a second IL-15/Fc eluate from the column; and to a purified interleukin­-15/Fc fusion protein and a composition, in particular a pharmaceutical composition, comprising such a fusion protein.