摘要 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis , liver cirrhosis and asthma, and cancer.
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申请人 |
CJ CORP.;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;JEIL PHARM. CO., LTD.;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
LEE, JANG HYUK;KWON, SOON JI;KIM, JONG HOON;KIM, NAM GEE;PARK, SUNG DAE;LEE, JEONG-HYUNG;KIM, SEUNG JUN;CHEON, HYAE GYEONG;JUNG, WON HOON;YOO, SUNG-EUN;KANG, SEUNG KYU;HUH, SUN CHUL;SONG, SEOG BEOM;AHN, JIN HEE;LEE, JAE MOK;RHEE, SANG DAL;KIM, SUNG SOO;KIM, KWANG-ROK;YANG, SUNG-DON |