DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH C-C CHEMOKINE RECEPTOR 2 (CCR2)

摘要

The invention provides a human CCR2 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, inflammatory diseases, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, inflammatory diseases, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR2 as well as pharmaceutical compositions comprising such compounds.